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Predicting anthropometric and metabolic traits with a genetic risk score for obesity in a sample of Pakistanis.

Scientific reports - 15 Apr 2021

Rana Sobia, Bhatti Adil Anwar

Abstract excerpt

Obesity is an outcome of multiple factors including environmental and genetic influences. Common obesity is a polygenic trait indicating that multiple genetic variants act synergistically to influence its expression. We constructed a genetic risk score (GRS) based on five genetic variants (MC4R rs17782313, BDNF rs6265, FTO rs1421085, TMEM18 rs7561317, and NEGR1 rs2815752) and examined its association with...

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Adolescent
Adult
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Body Weights and Measures
Brain-Derived Neurotrophic Factor
Cell Adhesion Molecules, Neuronal
Child
GPI-Linked Proteins
Genetic Association Studies
Genetic Variation
Humans
Membrane Proteins
Middle Aged
Multifactorial Inheritance
Obesity
Pakistan
Phenotype
Receptor, Melanocortin, Type 4

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Open in PubMed Open full text

Identifiers

PMID: 33859285
DOI: 10.1038/s41598-021-87702-0
PMCID: PMC8050295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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