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Article

Germline mutations and age at onset of lung adenocarcinoma.

Cancer - 1 Aug 2021

Reckamp Karen L, Behrendt Carolyn E, Slavin Thomas P, Gray Stacy W, Castillo Danielle K, Koczywas Marianna, Cristea Mihaela C, Babski Kirsten M, Stearns Donna, Marcum Catherine A, Rodriguez Yenni P, Hass Amie J, Vecchio Mary M, Mora Pamela, Cervantes Aleck E, Sand Sharon R, Mejia Rosa M, Tsou Terrence C, Salgia Ravi, Weitzel Jeffrey N

Abstract excerpt

BACKGROUND: To identify additional at-risk groups for lung cancer screening, which targets persons with a long history of smoking and thereby misses younger or nonsmoking cases, the authors evaluated germline pathogenic variants (PVs) in patients with lung adenocarcinoma for an association with an accelerated onset. METHODS: The authors assembled a retrospective cohort (1999-2018) of oncogenetic clinic patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33858029
DOI: 10.1002/cncr.33573
PMCID: PMC8794435

Genes

BRCA2
EGFR
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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