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Article

Antibiotic resistance heterogeneity and LasR diversity within Pseudomonas aeruginosa populations from pneumonia in intensive care unit patients.

International journal of antimicrobial agents - 1 Jun 2021

Crémet Lise, Leroy Anne-Gaëlle, Muller Damien, Delanou Sandie, Burghelea Alexandra, Broquet Alexis, Roquilly Antoine, Caroff Nathalie

Abstract excerpt

This study investigated within-host heterogeneity of 66 Pseudomonas aeruginosa populations from pneumonia in 51 critically ill ventilated patients by examining 30 colonies per bronchoalveolar lavage (BAL). Differences in antibiotic susceptibility and quorum-sensing (QS) phenotypes were observed between the members of 14 (21.2%) and 10 (15.2%) populations, respectively. A significant association was found between...

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PMID: 33857540
DOI: 10.1016/j.ijantimicag.2021.106341

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