Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations.

Abstract excerpt

Accurate methods to assess the pathogenicity of mutations are needed to fully leverage the possibilities of genome sequencing in diagnosis. Current data-driven and bioinformatics approaches are, however, limited by the large number of new variations found in each newly sequenced genome, and often do not provide direct mechanistic insight. Here we demonstrate, for the first time, that saturation mutagenesis,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Colorectal Neoplasms, Hereditary Nonpolyposis
• Share to Computer Simulation