Article
Interference of nuclear mitochondrial DNA segments in mitochondrial DNA testing resembles biparental transmission of mitochondrial DNA in humans.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Aug 2021
Bai Renkui, Cui Hong, Devaney Joseph M, Allis Katrina M, Balog Amanda M, Liu Xinyue, Schnur Rhonda E, Shapiro Faye L, Brautbar Ariel, Estrada-Veras Juvianee I, Hochstetler Laurel, McConkie-Rosell Allyn, McDonald Marie T, Solomon Benjamin D, Hofherr Sean, Richard Gabriele, Suchy Sharon F
Abstract excerpt
PURPOSE: Reports have questioned the dogma of exclusive maternal transmission of human mitochondrial DNA (mtDNA), including the recent report of an admixture of two mtDNA haplogroups in individuals from three multigeneration families. This was interpreted as being consistent with biparental transmission of mtDNA in an autosomal dominant-like mode. The authenticity and frequency of these findings are debated....
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