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Article

CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells.

The international journal of biochemistry & cell biology - 1 Jun 2021

García Rocío, Falduti Camila, Clauzure Mariángeles, Jara Raquel, Massip-Copiz María M, de Los Ángeles Aguilar María, Santa-Coloma Tomás A, Valdivieso Ángel G

Abstract excerpt

The impairment of the CFTR channel activity, a cAMP-activated chloride (Cl-) channel responsible for cystic fibrosis (CF), has been associated with a variety of mitochondrial alterations such as modified gene expression, impairment in oxidative phosphorylation, increased reactive oxygen species (ROS), and a disbalance in calcium homeostasis. The mechanisms by which these processes occur in CF are not fully...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33845203
DOI: 10.1016/j.biocel.2021.105976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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