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Article

Multimodal investigation of rat hepatitis E virus antigenicity: Implications for infection, diagnostics, and vaccine efficacy.

Journal of hepatology - 1 Jun 2021

Sridhar Siddharth, Situ Jianwen, Cai Jian-Piao, Yip Cyril Chik-Yan, Wu Shusheng, Zhang Anna Jin-Xia, Wen Lei, Chew Nicholas Foo-Siong, Chan Wan-Mui, Poon Rosana Wing-Shan, Chan Jasper Fuk-Woo, Tsang Dominic Ngai-Chong, Chen Honglin, Xia Ning-Shao, Yuen Kwok-Yung

Abstract excerpt

BACKGROUND & AIMS: Rat hepatitis E virus (Orthohepevirus species C; HEV-C1) is an emerging cause of viral hepatitis in humans. HEV-C1 is divergent from other HEV variants infecting humans that belong to Orthohepevirus species A (HEV-A). This study assessed HEV-C1 antigenic divergence from HEV-A and investigated the impact of this divergence on infection susceptibility, serological test sensitivity, and vaccine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33845058
DOI: 10.1016/j.jhep.2020.12.028

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