Substantial spillover burden of rat hepatitis E virus in humans.

doi:10.1038/s41467-025-59345-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Substantial spillover burden of rat hepatitis E virus in humans.

Nature communications - 29 Apr 2025

Chen Zihao, Wang Lifeng, Zhang Yongde, Li Guanghui, Yin Jiaxiang, Fan Jingyan, Liu Tianxu, Wu Han, Huang Yue, Huang Wenhui, Liu Donglin, Zheng Xiaoxiang, Zang Xia, Huang Xingcheng, Song Liuwei, Wen Shunhua, Li Jiayu, Ying Dong, Fang Mujin, Wang Yingbin, Wu Ting, Sridhar Siddharth, Zhang Jun, Xia Ningshao, Wang Lin, Lu Yihan, Zheng Zizheng

Abstract excerpt

The emergence of Rocahepevirus ratti genotype 1 (rat hepatitis E virus; rat HEV) in humans presents an unprecedented threat; however, the risk of rat HEV transmission to humans is not well understood. Here, we report the "Distinguishing Antibody Response Elicitation (DARE)" method, which distinguishes exposure to rat HEV. We use four study sets from China for large-scale population analysis: set 1 (hospital...

Read the complete abstract on PubMed

Topics

Animals
Humans
Hepatitis E virus
Rats
Hepatitis E

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

China

Male

Genotype

Female

Phylogeny

Adult

Middle Aged

Viral Zoonoses

Child

Zoonoses

Adolescent

Source

Open in PubMed Open full text

Identifiers

PMID: 40301345
DOI: 10.1038/s41467-025-59345-6
PMCID: PMC12041280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Substantial spillover burden of rat hepatitis E virus in humans.PMID 40301345Read ↗

Spillover of rat hepatitis E virus into humans: an emerging zoonosis?Semantic proximity Read ↗

Rocahepevirus ratti as an Emerging Cause of Acute Hepatitis WorldwideSemantic proximity Read ↗

Genomic characterization of Rocahepevirus ratti hepatitis E virus genotype C1 in Yunnan province of China.Semantic proximity Read ↗

High prevalence of rat hepatitis E virus in wild rats in China.Semantic proximity Read ↗

Review of Hepatitis E Virus in Rats: Evident Risk of Species Orthohepevirus C to Human Zoonotic Infection and DiseaseSemantic proximity Read ↗

Prevalence, Risk Factors, and Genetic Evolution of Rat Hepatitis E Virus in Small Mammals from Southwestern Yunnan, ChinaSemantic proximity Read ↗

Redeveloping antigen detection kits for the diagnosis of rat hepatitis E virusSemantic proximity Read ↗

Cell binding tropism of rat hepatitis E virus is a pivotal determinant of its zoonotic transmission to humansSemantic proximity Read ↗

Epidemiology and genetic diversity of zoonotic pathogens in urban rats (Rattus spp.) from a subtropical city, Guangzhou, southern China.Semantic proximity Read ↗

Epidemiological Peculiarities of the Hepatitis E Virus Infection in Brazil: A Scoping ReviewSemantic proximity Read ↗

Epidemiology of zoonotic hepatitis E: a community-based surveillance study in a rural population in China.Semantic proximity Read ↗

Prevalence and molecular characterization of hepatitis E virus (HEV) from wild rodents in Hubei Province, China.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.