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Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis

24 Mar 2021

Abstract excerpt

Traditionally, immunoglobulin (Ig) was believed to be produced by only B-lineage cells. However, increasing evidence has revealed a high level of Ig expression in cancer cells, and this Ig is named cancer-derived Ig. Further studies have shown that cancer-derived Ig shares identical basic structures with B cell-derived Ig but exhibits several distinct characteristics, including restricted variable region...

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PMID: 33841396
DOI: 10.3389/fimmu.2021.613530

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