Characterization of H5N1 avian influenza virus isolated from bird in Russia with the E627K mutation in the PB2 protein.

doi:10.1038/s41598-024-78175-y

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Characterization of H5N1 avian influenza virus isolated from bird in Russia with the E627K mutation in the PB2 protein.

Scientific reports - 3 Nov 2024

Marchenko Vasiliy Yu, Panova Anastasia S, Kolosova Natalia P, Gudymo Andrey S, Svyatchenko Svetlana V, Danilenko Alexey V, Vasiltsova Natalia N, Egorova Marina L, Onkhonova Galina S, Zhestkov Pavel D, Zinyakov Nikolay G, Andreychuk Dmitriy B, Chvala Ilya A, Kosenko Maksim N, Moiseeva Anastasia A, Boldyrev Nikita D, Shadrinova Kiunnei N, Perfilieva Olga N, Ryzhikov Alexander B

Abstract excerpt

Currently A(H5Nx) avian influenza viruses are globally widespread and continue to evolve. Since their emergence in 2020 novel highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b reassortant viruses have become predominant in the world and caused multiple infections in mammals. It was shown that some of A(H5N1) viruses mostly isolated from mammals contain an E627K mutation in the PB2 protein which can lead to...

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PMID: 39489822
DOI: 10.1038/s41598-024-78175-y
PMCID: PMC11532466

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