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Article

Thyrotroph embryonic factor polymorphism predicts faster progression of Parkinson's disease in a longitudinal study.

Journal of integrative neuroscience - 30 Mar 2021

Hua Ping, Cui Can, Chen Yong, Yao Yan, Yu Cui-Yu, Xu Li-Gang, Liu Wei-Guo

Abstract excerpt

The thyrotroph embryonic factor gene is a circadian clock-controlled gene. The rs738499 polymorphism of this gene has been suggested to be associated with depression and sleep disturbance in Parkinson's disease in previous cross-sectional studies. We aimed to investigate whether this single nucleotide polymorphism is associated with the progression rates of various motor and non-motor symptoms in patients with...

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PMID: 33834695
DOI: 10.31083/j.jin.2021.01.366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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