Tef polymorphism is associated with sleep disturbances in patients with Parkinson's disease.

Abstract excerpt

OBJECTIVE: Circadian mechanisms play an important role in the regulation of sleep. A circadian clock-controlled gene, Tef, has been suggested to be associated with depressive symptoms, restless legs syndrome, and slow wave sleep in patients with sleep disorders. The present study sought to explore the association between Tef and sleep disturbances in patients with Parkinson's disease (PD). METHODS: Three hundred...

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