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Article

Hierarchical mixed-model expedites genome-wide longitudinal association analysis.

Briefings in bioinformatics - 2 Sept 2021

Zhang Ying, Song Yuxin, Gao Jin, Zhang Hengyu, Yang Ning, Yang Runqing

Abstract excerpt

A hierarchical random regression model (Hi-RRM) was extended into a genome-wide association analysis for longitudinal data, which significantly reduced the dimensionality of repeated measurements. The Hi-RRM first modeled the phenotypic trajectory of each individual using a RRM and then associated phenotypic regressions with genetic markers using a multivariate mixed model (mvLMM). By spectral decomposition of...

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PMID: 33834187
DOI: 10.1093/bib/bbab096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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