Article
Genetic variants related to successful migraine prophylaxis with verapamil.
Molecular genetics & genomic medicine - 1 Jun 2021
Cutrer Fred Michael, Moyer Ann M, Atkinson Elizabeth J, Wang Liguo, Tian Shulan, Wu Yanhong, Garza Ivan, Robertson Carrie E, Huebert Carey A, Moore Brenda E, Klein Christopher J
Abstract excerpt
BACKGROUND: Currently, there is no biologically based rationale for drug selection in migraine prophylactic treatment. METHODS: To investigate the genetic variation underlying treatment response to verapamil prophylaxis, we selected 225 patients from a longitudinally established, deeply phenotyped migraine database (N = 5983), and collected uninterrupted quantitated verapamil treatment response data and DNA for...
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