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Article

Localized ALK-positive histiocytosis in a Chinese woman: report of a case in the lung with a novel EML4-ALK rearrangement.

Virchows Archiv : an international journal of pathology - 1 Dec 2021

Bai Yanhua, Sun Wei, Niu Dongfeng, Yang Xin, Diao Xinting, Yu Yang, Lin Dongmei

Abstract excerpt

ALK-positive histiocytosis (APH) is a newly defined entity with specific histological features and a highly recurrent KIF5B-ALK gene fusion. APH is characterized by clonal proliferation of histiocytes and can present as either systemic or localized. It was first described in infants and then expanded to older children and adults. Although lung involvement has been shown in three systemic cases, localized lung...

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Identifiers

PMID: 33825946
DOI: 10.1007/s00428-021-03092-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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