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Article

Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae.

Genome medicine - 30 Mar 2021

Yahara Koji, Ma Kevin C, Mortimer Tatum D, Shimuta Ken, Nakayama Shu-Ichi, Hirabayashi Aki, Suzuki Masato, Jinnai Michio, Ohya Hitomi, Kuroki Toshiro, Watanabe Yuko, Yasuda Mitsuru, Deguchi Takashi, Eldholm Vegard, Harrison Odile B, Maiden Martin C J, Grad Yonatan H, Ohnishi Makoto

Abstract excerpt

BACKGROUND: Antimicrobial resistance in Neisseria gonorrhoeae is a global health concern. Strains from two internationally circulating sequence types, ST-7363 and ST-1901, have acquired resistance to third-generation cephalosporins, mainly due to mosaic penA alleles. These two STs were first detected in Japan; however, the timeline, mechanism, and process of emergence and spread of these mosaic penA alleles to...

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Identifiers

PMID: 33785063
DOI: 10.1186/s13073-021-00860-8
PMCID: PMC8008663

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