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Article

Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928-2013): antimicrobial use/misuse selects for resistance and drives evolution.

BMC genomics - 3 Feb 2020

Golparian Daniel, Harris Simon R, Sánchez-Busó Leonor, Hoffmann Steen, Shafer William M, Bentley Stephen D, Jensen Jörgen S, Unemo Magnus

Abstract excerpt

BACKGROUND: Multidrug-resistant Neisseria gonorrhoeae strains are prevalent, threatening gonorrhoea treatment globally, and understanding of emergence, evolution, and spread of antimicrobial resistance (AMR) in gonococci remains limited. We describe the genomic evolution of gonococci and their AMR, related to the introduction of antimicrobial therapies, examining isolates from 1928 (preantibiotic era) to 2013 in...

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Identifiers

PMID: 32013864
DOI: 10.1186/s12864-020-6511-6
PMCID: PMC6998845

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