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Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

25 Mar 2021

Abstract excerpt

Poor maternal diet increases the risk of obesity and type 2 diabetes in offspring, adding to the ever-increasing prevalence of these diseases. In contrast, we find that maternal exercise improves the metabolic health of offspring, and here, we demonstrate that this occurs through a vitamin D receptor-mediated increase in placental superoxide dismutase 3 (SOD3) expression and secretion. SOD3 activates an AMPK/TET...

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PMID: 33770509
DOI: 10.1016/j.cmet.2021.03.004

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