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Article

Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes

20 May 2020

Abstract excerpt

Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term health. The underlying mechanisms and effective interventions to abrogate such effect remain unclear. Our previous studies demonstrated impaired mitochondrial biogenesis in male human placenta of diabetic mothers. In the present studies, epigenetic marks...

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PMID: 32433500
DOI: 10.1038/s41598-020-65415-0

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