Article
Cytolytic activity score as a biomarker for antitumor immunity and clinical outcome in patients with gastric cancer.
Cancer medicine - 1 May 2021
Hu Qingjiang, Nonaka Kentaro, Wakiyama Hiroaki, Miyashita Yu, Fujimoto Yoshiaki, Jogo Tomoko, Hokonohara Kentaro, Nakanishi Ryota, Hisamatsu Yuichi, Ando Koji, Kimura Yasue, Masuda Takaaki, Oki Eiji, Mimori Koshi, Oda Yoshinao, Mori Masaki
Abstract excerpt
BACKGROUND: A simple measure of immune cytolytic activity (CYT) base on mRNA expression levels of two genes, GZMA and PRF1, was recently reported. Here, we aimed to evaluate the CYT score's potential as a measure of antitumor immunity and predictor of clinical outcome in gastric cancer (GC) patients. MATERIALS AND METHODS: We evaluated the correlations between tumor-infiltrating immune cells and the CYT score in...
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