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Article

High cumulative risk of colorectal cancers and desmoid tumours and fibromatosis in South Asian APC mutation carriers.

Journal of medical genetics - 1 May 2022

Ashar Shivani, Lipsa Anuja, Khan Nikhat, Sarin Rajiv

Abstract excerpt

Management of familial adenomatous polyposis (FAP) is guided by the cumulative risk of colorectal cancer (CRC) and aggressive fibromatosis/desmoid (AF/D). The first non-Caucasian FAP cohort with cumulative risk estimates for CRC and AF/D shows distinct differences with the Caucasian and other Asian cohorts. The strong correlation between the adenomatous polyposis coli (APC) mutation location with the FAP...

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PMID: 33766935
DOI: 10.1136/jmedgenet-2021-107731

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