Article
Tumor-infiltrating plasmacytoid dendritic cells are associated with survival in human colon cancer.
Journal for immunotherapy of cancer - 1 Mar 2021
Kießler Maximilian, Plesca Ioana, Sommer Ulrich, Wehner Rebekka, Wilczkowski Friederike, Müller Luise, Tunger Antje, Lai Xixi, Rentsch Anke, Peuker Kenneth, Zeissig Sebastian, Seifert Adrian M, Seifert Lena, Weitz Jürgen, Bachmann Michael, Bornhäuser Martin, Aust Daniela, Baretton Gustavo, Schmitz Marc
Abstract excerpt
BACKGROUND: Plasmacytoid dendritic cells (pDCs) play a key role in the induction and maintenance of antitumor immunity. Conversely, they can act as tolerogenic DCs by inhibiting tumor-directed immune responses. Therefore, pDCs may profoundly influence tumor progression. To gain novel insights into the role of pDCs in colon cancer, we investigated the frequency and clinical relevance of pDCs in primary tumor...
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