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Article

DNA hypermethylation of PTPN22 gene promoter in children and adolescents with Hashimoto thyroiditis.

Journal of endocrinological investigation - 1 Oct 2021

Kyrgios I, Giza S, Fragou A, Tzimagiorgis G, Galli-Tsinopoulou A

Abstract excerpt

PURPOSE: Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is an inhibitor of T-cell activation, regulating intracellular signal transduction and thereby being implicated in the pathogenesis of autoimmune thyroid disease (AITD). The exact molecular mechanisms have not been fully elucidated. The aim of the present study was to quantitate DNA methylation within the PTPN22 gene promoter in children and...

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Identifiers

PMID: 33751486
DOI: 10.1007/s40618-020-01463-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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