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Article

HTRA1 Variants and the Interaction with Smoking Confer the Genetic Susceptibility to Ischemic Stroke.

International journal of medical sciences - 1 Jan 2021

Tian Yuanrui, Tang Wuzhuang, Yang Song, Zhao Yanping, Chen Yanchun, Zhao Xianghai, Liu Chunlan, Chen Xiaotian, Shen Chong

Abstract excerpt

High temperature requirement protein A1 (HtrA1) was identified as the causative gene of autosomal recessive arteriopathy and associated with lacunar ischemic stroke (IS) in European. This study aimed at evaluating the association of HTRA1 with IS and four tagging single-nucleotide polymorphisms (SNPs) were genotyped in a cohort of 4,098 Chinese. The mRNA level of HTRA1 in 72 IS cases and 72 hypertension controls...

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Identifiers

PMID: 33746601
DOI: 10.7150/ijms.45856
PMCID: PMC7976583

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