Article
[Association study on single nucleotide polymorphisms in HTRA1 gene and rheumatoid arthritis].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Jun 2010
Luo Rui-jun, Zhang Ding-ding, Zhu Jing, Zhou Bin, Ma Shi, Lu Fang, Liu Jian, Long Wu-bin, Yang Zheng-lin, Zhang Chong-jie
Abstract excerpt
OBJECTIVE: To study the association between the single nucleotide polymorphisms (SNPs) in the high-temperature requirement A-1 (HTRA1) gene and rheumatoid arthritis (RA) in Chinese Han population. METHODS: Five SNPs in the HTRA1 gene (rs2014307, rs2248799, rs2300433, rs714816 and rs2268356) were genotyped by ABI Snapshot method in Han Chinese cohort composed of 344 patients with RA and 288 healthy controls. The...