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Evaluation of a nationwide Dutch guideline to detect Lynch syndrome in patients with endometrial cancer.

Gynecologic oncology - 1 Mar 2021

Tjalsma A S, Wagner A, Dinjens W N M, Ewing-Graham P C, Alcalá L S M, de Groot M E R, Hamoen K E, van Hof A C, Hofhuis W, Hofman L N, Hoogduin K J, Kaijser J, Makkus A C F, Mol S J J, Plaisier G M, Schelfhout K, Smedts H P M, Smit R A, Timmers P J, Vencken P M L H, Visschers B, van der Wurff A A M, van Doorn H C

Abstract excerpt

OBJECTIVE: In the Netherlands a nationwide guideline was introduced in 2016, which recommended routine Lynch syndrome screening (LSS) for all women with endometrial cancer (EC) <70 years of age. LSS consists of immunohistochemical (IHC) staining for loss of mismatch repair (MMR) protein expression, supplemented with MLH1 methylation analysis if indicated. Test results are evaluated by the treating gynaecologist,...

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Identifiers

PMID: 33419609
DOI: 10.1016/j.ygyno.2020.12.028

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