Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials.

doi:10.1158/1078-0432.CCR-20-4731

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Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2021

Upadhyaya Santhosh A, Robinson Giles W, Onar-Thomas Arzu, Orr Brent A, Johann Pascal, Wu Gang, Billups Catherine A, Tatevossian Ruth G, Dhanda Sandeep Kumar, Srinivasan Ashok, Broniscer Alberto, Qaddoumi Ibrahim, Vinitsky Anna, Armstrong Gregory T, Bendel Anne E, Hassall Tim, Partap Sonia, Fisher Paul G, Crawford John R, Chintagumpala Murali, Bouffet Eric, Gururangan Sridharan, Mostafavi Roya, Sanders Robert P, Klimo Paul, Patay Zoltan, Indelicato Daniel J, Nichols Kim E, Boop Frederick A, Merchant Thomas E, Kool Marcel, Ellison David W, Gajjar Amar

Abstract excerpt

PURPOSE: Report relevance of molecular groups to clinicopathologic features, germline SMARCB1/SMARCA4 alterations (GLA), and survival of children with atypical teratoid rhabdoid tumor (ATRT) treated in two multi-institutional clinical trials. MATERIALS AND METHODS: Seventy-four participants with newly diagnosed ATRT were treated in two trials: infants (SJYC07: age < 3 years; n = 52) and children (SJMB03: age 3-21...

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PMID: 33737307
DOI: 10.1158/1078-0432.CCR-20-4731
PMCID: PMC8127412

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