Association of HLA-DRB1*09:01 with severe COVID-19.

doi:10.1111/tan.14256

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Article

Association of HLA-DRB1*09:01 with severe COVID-19.

HLA - 1 Jul 2021

Anzurez Alitzel, Naka Izumi, Miki Shoji, Nakayama-Hosoya Kaori, Isshiki Mariko, Watanabe Yusuke, Nakamura-Hoshi Midori, Seki Sayuri, Matsumura Takayuki, Takano Tomohiro, Onodera Taishi, Adachi Yu, Moriyama Saya, Terahara Kazutaka, Tachikawa Natsuo, Yoshimura Yoshihiro, Sasaki Hiroaki, Horiuchi Hiroshi, Miyata Nobuyuki, Miyazaki Kazuhito, Koga Michiko, Ikeuchi Kazuhiko, Nagai Hiroyuki, Saito Makoto, Adachi Eisuke, Yotsuyanagi Hiroshi, Kutsuna Satoshi, Kawashima Akira, Miyazato Yusuke, Kinoshita Noriko, Kouno Chiyoko, Tanaka Kensuke, Takahashi Yoshimasa, Suzuki Tadaki, Matano Tetsuro, Ohashi Jun, Kawana-Tachikawa Ai

Abstract excerpt

HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB1*09:01 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus...

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PMID: 33734601
DOI: 10.1111/tan.14256
PMCID: PMC8251239

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