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Article

GOPC-ROS1 mosaicism in agminated Spitz naevi: report of two cases.

Virchows Archiv : an international journal of pathology - 1 Sept 2021

Goto Keisuke, Pissaloux Daniel, Kauer Friederike, Huriet Véronique, Tirode Franck, de la Fouchardière Arnaud

Abstract excerpt

Spitz tumors are genetically associated with activating HRAS point mutations or fusions of either ALK, ROS1, NTRK1, NTRK3, RET, MET, MERTK, LCK, BRAF, MAP3K8, or MAP3K3. All these driver gene alterations are mutually exclusive. We report two cases of agminated Spitz naevi with a GOPC-ROS1 fusion. Both cases occurred on the lower limb of young adults. Since adolescence, pigmented or pink-colored papules have been...

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PMID: 33733342
DOI: 10.1007/s00428-020-02992-5

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