Article
Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses.
BMC medicine - 18 Mar 2021
Bos Maxime M, Goulding Neil J, Lee Matthew A, Hofman Amy, Bot Mariska, Pool René, Vijfhuizen Lisanne S, Zhang Xiang, Li Chihua, Mustafa Rima, Neville Matt J, Li-Gao Ruifang, Trompet Stella, Beekman Marian, Biermasz Nienke R, Boomsma Dorret I, de Boer Irene, Christodoulides Constantinos, Dehghan Abbas, van Dijk Ko Willems, Ford Ian, Ghanbari Mohsen, Heijmans Bastiaan T, Ikram M Arfan, Jukema J Wouter, Mook-Kanamori Dennis O, Karpe Fredrik, Luik Annemarie I, Lumey L H, van den Maagdenberg Arn M J M, Mooijaart Simon P, de Mutsert Renée, Penninx Brenda W J H, Rensen Patrick C N, Richmond Rebecca C, Rosendaal Frits R, Sattar Naveed, Schoevers Robert A, Slagboom P Eline, Terwindt Gisela M, Thesing Carisha S, Wade Kaitlin H, Wijsman Carolien A, Willemsen Gonneke, Zwinderman Aeilko H, van Heemst Diana, Noordam Raymond, Lawlor Deborah A
Abstract excerpt
BACKGROUND: Sleep traits are associated with cardiometabolic disease risk, with evidence from Mendelian randomization (MR) suggesting that insomnia symptoms and shorter sleep duration increase coronary artery disease risk. We combined adjusted multivariable regression (AMV) and MR analyses of phenotypes of unfavourable sleep on 113 metabolomic traits to investigate possible biochemical mechanisms linking sleep to...
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