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Article

Anomalies in human sex determination provide unique insights into the complex genetic interactions of early gonad development.

Clinical genetics - 1 Feb 2017

Bashamboo A, Eozenou C, Rojo S, McElreavey K

Abstract excerpt

Human sex determination (SD) involves complex mutually antagonistic genetic interactions of testis- and ovary-determining pathways. For many years, both male and female SD were considered to be regulated by a linear cascade of pro-male and pro-female genes, respectively; however, it has become clear that male and female development is achieved through the repression of the alternative state. A gene determining...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27893151
DOI: 10.1111/cge.12932

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