Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in hsa-mir-23a-5p, -193a-5p, and -193b-5p and insulin-like growth factor 2 expression.

doi:10.1096/fj.202002156RRR

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in hsa-mir-23a-5p, -193a-5p, and -193b-5p and insulin-like growth factor 2 expression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2021

Mirra Paola, Desiderio Antonella, Spinelli Rosa, Nigro Cecilia, Longo Michele, Parrillo Luca, D'Esposito Vittoria, Carissimo Annamaria, Hedjazifar Shahram, Smith Ulf, Formisano Pietro, Miele Claudia, Raciti Gregory A, Beguinot Francesco

Abstract excerpt

First-degree relatives (FDRs) of type 2 diabetics (T2D) feature dysfunction of subcutaneous adipose tissue (SAT) long before T2D onset. miRNAs have a role in adipocyte precursor cells (APC) differentiation and in adipocyte identity. Thus, impaired miRNA expression may contribute to SAT dysfunction in FDRs. In the present work, we have explored changes in miRNA expression associated with T2D family history which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Diabetes Mellitus, Type 2

Share to Family

Share to Gene Expression Regulation

Share to Genetic Predisposition to Disease

Share to Insulin-Like Growth Factor II

Share to MicroRNAs

Source

Open in PubMed

Identifiers

PMID: 33710685
DOI: 10.1096/fj.202002156RRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in hsa-mir-23a-5p, -193a-5p, and -193b-5p and insulin-like growth factor 2 expression.PMID 33710685Read ↗

miR-223-3p as a potential biomarker and player for adipose tissue dysfunction preceding type 2 diabetes onsetSemantic proximity Read ↗

Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabeticsSemantic proximity Read ↗

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis.Semantic proximity Read ↗

Pre-diabetes linked microRNA miR-193b-3p targets PPARGC1A and increases lipid accumulation in hepatocytes: potential biomarker of fatty liver diseaseSemantic proximity Read ↗

Integrated miRNA–mRNA Analysis Reveals Dysregulated Regulatory Networks in Visceral Adipose Tissue Linked to Obesity and Type 2 DiabetesSemantic proximity Read ↗

Role of MicroRNAs in the Regulation of Subcutaneous White Adipose Tissue in Individuals With Obesity and Without Type 2 DiabetesSemantic proximity Read ↗

Whole transcriptome RNA-seq reveals key regulatory factors involved in type 2 diabetes pathology in peripheral fat of Asian IndiansSemantic proximity Read ↗

Adipocyte hypertrophy, inflammation and fibrosis characterize subcutaneous adipose tissue of healthy, non-obese subjects predisposed to type 2 diabetes.Semantic proximity Read ↗

MicroRNAs in β-Cell Biology, Insulin Resistance, Diabetes and Its ComplicationsSemantic proximity Read ↗

Epigenetic regulation of diabetogenic adipose morphologySemantic proximity Read ↗

MiRNA Expression Profile of Human Subcutaneous Adipose and during Adipocyte DifferentiationSemantic proximity Read ↗

The involvement of microRNAs in Type 2 diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.