Human cardiosphere-derived stromal cells exposed to SARS-CoV-2 evolve into hyper-inflammatory/pro-fibrotic phenotype and produce infective viral particles depending on the levels of ACE2 receptor expression.

doi:10.1093/cvr/cvab082

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Human cardiosphere-derived stromal cells exposed to SARS-CoV-2 evolve into hyper-inflammatory/pro-fibrotic phenotype and produce infective viral particles depending on the levels of ACE2 receptor expression.

Cardiovascular research - 25 May 2021

Amendola Alessandra, Garoffolo Gloria, Songia Paola, Nardacci Roberta, Ferrari Silvia, Bernava Giacomo, Canzano Paola, Myasoedova Veronika, Colavita Francesca, Castilletti Concetta, Sberna Giuseppe, Capobianchi Maria Rosaria, Piacentini Mauro, Agrifoglio Marco, Colombo Gualtiero Ivanoe, Poggio Paolo, Pesce Maurizio

Abstract excerpt

AIMS: Patients with severe respiratory syndrome caused by SARS-CoV-2 undergo cardiac complications due to hyper-inflammatory conditions. Although the presence of the virus has been detected in the myocardium of infected patients, and infection of induced pluripotent cell-derived cardiomyocytes has been demonstrated, the reported expression of Angiotensin-Converting Enzyme-2 (ACE2) in cardiac stromal cells...

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PMID: 33705542
DOI: 10.1093/cvr/cvab082
PMCID: PMC7989620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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