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Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model–Based Study

10 Mar 2021

Abstract excerpt

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism and insulin resistance (IR); however, the pathogenesis of local ovarian IR in PCOS remains largely unclear. Humanin, a mitochondria-derived peptide, has been reported to be associated with IR. Our previous study confirmed that humanin is expressed in multiple cell types in the...

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PMID: 33693742
DOI: 10.1210/endocr/bqab056

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