Article
Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells.
Neoplasia (New York, N.Y.) - 1 Nov 2023
Grottker Fridolin, Gehre Simon, Reichardt Clara M, Sengedorj Azzaya, Jost Tina, Rieckmann Thorsten, Hecht Markus, Gostian Antoniu-Oreste, Frey Benjamin, Fietkau Rainer, Gaipl Udo S, Rückert Michael
Abstract excerpt
PURPOSE: Human papilloma virus (HPV) positive head and neck squamous cell carcinoma (HNSCC) tumors respond significantly better to anticancer treatments. It is assumed to be due to a better response to radiotherapy (RT), and presumably to an increased immunogenicity. However, little is known how the immune phenotype of HNSCC tumor cells is modulated by standard treatment, namely by radiochemotherapy (RCT)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.