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Article

Antifibrotics Modify B-Cell–Induced Fibroblast Migration and Activation in Patients with Idiopathic Pulmonary Fibrosis

9 Mar 2021

Abstract excerpt

B-cell activation is increasingly linked to numerous fibrotic lung diseases, and it is well known that aggregates of lymphocytes form in the lung of many of these patients. Activation of B-cells by pattern recognition receptors (PRRs) drives the release of inflammatory cytokines, chemokines, and metalloproteases important in the pathophysiology of pulmonary fibrosis. However, the specific mechanisms of B-cell...

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PMID: 33689587
DOI: 10.1165/rcmb.2020-0387oc

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