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Is there still a rationale for non-invasive PGT-A by analysis of cell-free DNA released by human embryos into culture medium?

5 Feb 2021

Abstract excerpt

Human embryos utilise an array of processes to eliminate the very high prevalence of aneuploid cells in early embryo stages. Human embryo self-correction was recently demonstrated by their ability to eliminate/expel abnormal blastomeres as cell debris/fragments. A whole genome amplification study has demonstrated that 63.6% of blastocysts expelled cell debris with abnormal chromosomal rearrangements. Moreover,...

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PMID: 33686429
DOI: 10.1093/humrep/deab042

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