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Origin and composition of cell-free DNA in spent medium from human embryo culture during preimplantation development

26 Jan 2018

Abstract excerpt

STUDY QUESTION: What is the origin and composition of cell-free DNA in human embryo spent culture media? SUMMARY ANSWER: Cell-free DNA from human embryo spent culture media represents a mix of maternal and embryonic DNA, and the mixture can be more complex for mosaic embryos. WHAT IS KNOWN ALREADY: In 2016, ~300 000 human embryos were chromosomally and/or genetically analyzed using preimplantation genetic testing...

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PMID: 29471395
DOI: 10.1093/humrep/dey028

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