Article
Genome-Wide fitness analysis of group B Streptococcus in human amniotic fluid reveals a transcription factor that controls multiple virulence traits.
PLoS pathogens - 1 Mar 2021
Dammann Allison N, Chamby Anna B, Catomeris Andrew J, Davidson Kyle M, Tettelin Hervé, van Pijkeren Jan-Peter, Gopalakrishna Kathyayini P, Keith Mary F, Elder Jordan L, Ratner Adam J, Hooven Thomas A
Abstract excerpt
Streptococcus agalactiae (group B Streptococcus; GBS) remains a dominant cause of serious neonatal infections. One aspect of GBS that renders it particularly virulent during the perinatal period is its ability to invade the chorioamniotic membranes and persist in amniotic fluid, which is nutritionally deplete and rich in fetal immunologic factors such as antimicrobial peptides. We used next-generation sequencing...
Topics
- Amniotic Fluid
- Animals
- Bacterial Proteins
- Gene Expression Regulation, Bacterial
- Humans
- Mice
- Phenotype
- Streptococcal Infections
- Streptococcus agalactiae
- Transcription Factors