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Acquisition of cancer stem cell capacities after spontaneous cell fusion

7 Mar 2021

Abstract excerpt

BACKGROUND: Cancer stem/Initiating cell (CS/IC) hypothesis argues that CS/ICs are responsible of tumour initiation, drug resistance, metastasis or disease relapse. Their detection in several cancers supports this concept. However, their origin is still misunderstood. Cell fusion is shown to take part in the formation of CS/ICs, i.e. fusion between mesenchymal stem cell and cancer cell. In a previous paper, we...

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PMID: 33678155
DOI: 10.1186/s12885-021-07979-2

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