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Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

3 Mar 2021

Abstract excerpt

SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies against the viral spike (S). However, the merits of broadly targeting S versus focusing antibody onto the smaller receptor binding domain (RBD) are unclear. Here we assess prototypic S and RBD subunit vaccines in homologous or heterologous prime-boost regimens in mice and non-human...

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PMID: 33658497
DOI: 10.1038/s41467-021-21665-8

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