Article
OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia.
Blood cancer journal - 3 Mar 2021
Eisfelder Bartholomew J, Saygin Caner, Wynne Joseph, Colton Margaret W, Fischietti Mariafausta, Beauchamp Elspeth M, Cheng Jason X, Odenike Olatoyosi, Roboz Gail, Alachkar Houda, Stock Wendy
Abstract excerpt
Internal tandem duplication (-ITD) mutations of Fms-like tyrosine kinase 3 (FLT3) provide growth and pro-survival signals in the context of established driver mutations in FLT3 mutant acute myeloid leukemia (AML). Maternal embryonic leucine zipper kinase (MELK) is an aberrantly expressed gene identified as a target in AML. The MELK inhibitor OTS167 induces cell death in AML including cells with FLT3 mutations,...
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