Article
SNPs within microRNA binding sites and the prognosis of breast cancer.
Aging - 26 Feb 2021
Zhang Liwen, Han Lu, Huang Yubei, Feng Ziwei, Wang Xin, Li Haixin, Song Fangfang, Liu Luyang, Li Junxian, Zheng Hong, Wang Peishan, Song Fengju, Chen Kexin
Abstract excerpt
Single nucleotide polymorphisms (SNPs) within microRNA binding sites can affect the binding of microRNA to mRNA and regulate gene expression, thereby contributing to cancer prognosis. Here we performed a two-stage study of 2647 breast cancer patients to explore the association between SNPs within microRNA binding sites and breast cancer prognosis. In stage I, we genotyped 192 SNPs within microRNA binding sites...
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