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Bioinspired in vitro microenvironments to control cell fate: focus on macromolecular crowding.

American journal of physiology. Cell physiology - 1 May 2021

Zeugolis Dimitrios I

Abstract excerpt

The development of therapeutic regenerative medicine and accurate drug discovery cell-based products requires effective, with respect to obtaining sufficient numbers of viable, proliferative, and functional cell populations, cell expansion ex vivo. Unfortunately, traditional cell culture systems fail to recapitulate the multifaceted tissue milieu in vitro, resulting in cell phenotypic drift, loss of...

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PMID: 33656930
DOI: 10.1152/ajpcell.00380.2020

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