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Macromolecular crowding regulates matrix composition and gene expression in human gingival fibroblast cultures

4 Feb 2023

Abstract excerpt

Standard cell cultures are performed in aqueous media with a low macromolecule concentration compared to tissue microenvironment. In macromolecular crowding (MMC) experiments, synthetic polymeric crowders are added into cell culture media to better mimic macromolecule concentrations found in vivo. However, their effect on cultured cells is incompletely understood and appears context-dependent. Here we show using...

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PMID: 36739306
DOI: 10.1038/s41598-023-29252-1

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