Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development

Abstract excerpt

Significance A better understanding of the molecular mechanisms underlying the development of Plasmodium parasites in Anopheles mosquitoes would facilitate the development of malaria vaccines and of novel strategies to interrupt disease transmission. We characterized, at the single-cell level, the gene expression profiles of sporozoites from the rodent malaria parasite Plasmodium berghei , throughout their...

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