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Article

Differential Response of Lung Cancer Cells, with Various Driver Mutations, to Plant Polyphenol Resveratrol and Vitamin D Active Metabolite PRI-2191.

International journal of molecular sciences - 26 Feb 2021

Maj Ewa, Maj Beata, Bobak Klaudia, Gos Michalina, Chodyński Michał, Kutner Andrzej, Wietrzyk Joanna

Abstract excerpt

Plant polyphenols and vitamins D exhibit chemopreventive and therapeutic anticancer effects. We first evaluated the biological effects of the plant polyphenol resveratrol (RESV) and vitamin D active metabolite PRI-2191 on lung cancer cells having different genetic backgrounds. RESV and PRI-2191 showed divergent responses depending on the genetic profile of cells. Antiproliferative activity of PRI-2191 was...

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Identifiers

PMID: 33652978
DOI: 10.3390/ijms22052354
PMCID: PMC7956761

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