Article
Single nucleotide variants in immune-response genes and the tumor microenvironment composition predict progression of mantle cell lymphoma.
BMC cancer - 1 Mar 2021
Assis-Mendonça Guilherme Rossi, Fattori André, Rocha Rafael Malagoli, Lourenço Gustavo Jacob, Delamain Márcia Torresan, Nonogaki Suely, de Lima Vladmir Cláudio Cordeiro, Colleoni Gisele Wally Braga, de Souza Cármino Antonio, Soares Fernando Augusto, Lima Carmen Silvia Passos, Vassallo José
Abstract excerpt
BACKGROUND: There is evidence to consider that the tumor microenvironment (TME) composition associates with antitumor immune response, and may predict the outcome of various non-Hodgkin lymphoma subtypes. However, in the case of mantle cell lymphoma (MCL), a rare and aggressive disease, there is lacking a detailed study of the TME components, as well as an integrative approach among them in patients' samples....
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