Article
ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection.
Communications biology - 26 Feb 2021
Ni Shousheng, Zhou Yang, Song Lili, Chen Yan, Wang Xia, Du Xiaoyuan, Zhang Shicui
Abstract excerpt
Previous studies have shown that ELAVL1 plays multiple roles, but its overall biological function remains ill-defined. Here we clearly demonstrated that zebrafish ELAVL1a was a lipoteichoic acid (LTA)- and LPS-binding protein abundantly stored in the eggs/embryos of zebrafish. ELAVL1a acted not only as a pattern recognition receptor, capable of identifying LTA and LPS, as well as bacteria, but also as an effector...
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