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Article

Unique ethnic features of DDX41 mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia.

Haematologica - 1 Feb 2022

Choi Eun-Ji, Cho Young-Uk, Hur Eun-Hye, Jang Seongsoo, Kim Nayoung, Park Han-Seung, Lee Jung-Hee, Lee Kyoo-Hyung, Kim Si-Hwan, Hwang Sang-Hyun, Seo Eul-Ju, Park Chan-Jeoung, Lee Je-Hwan

Abstract excerpt

DDX41 mutations are associated with hematologic malignancies including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), but the incidence in idiopathic cytopenia of undetermined significance (ICUS) is unknown. We investigated the incidence, genetic characteristics, and clinical features of DDX41 mutations in Korean patients with ICUS, MDS, or AML. We performed targeted deep sequencing of 61 genes...

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Identifiers

PMID: 33626862
DOI: 10.3324/haematol.2020.270553
PMCID: PMC8804579

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